Articles Tagged With:
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Nirmatrelvir-Ritonavir in High-Risk Vaccinated and Low-Risk Unvaccinated Participants: The EPIC-SR Trial
In this Phase II-III randomized controlled clinical trial (EPIC-SR), nirmatrelvir-ritonavir was not associated with a significant difference in time to alleviation of symptoms nor COVID-19-related hospitalization or death from any cause as compared with placebo in unvaccinated individuals without risk factors for severe disease or in vaccinated individuals with a least one risk factor for severe disease.
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High-Mortality Cryptococcosis Infection After COVID-19
A survey initiated by the Mycoses Study Group identified 69 cases of cryptococcosis following COVID-19 infection. The mortality rate was 59%, with cases in both immunocompromised and immunocompetent individuals.
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Meningococcal Disease Is on the Rise
The number of cases of infection with Neisseria meningitidis is increasing in the United States. The majority of presentations are with bacteremia; meningitis is infrequent.
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More than Half of 2024 Measles Cases Hospitalized
A measles outbreak continues to hit Chicago, while surveillance nationally found 113 cases in 18 states as of April 4, 2024. With cases both in the community and in migrant shelters, the Chicago Health Department reported 61 measles infections as of April 11, 2024.
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Predicting Outcomes of Congenital Cytomegalovirus Infection
Congenital cytomegalovirus infection can cause hearing loss and neurologic deficits, but most affected newborns escape without sequelae. New data suggest a good prognosis if the mother’s infection was after the first trimester and if the newborn has normal hearing, a normal platelet count, and a normal head ultrasound exam.
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CDC Issues Alert on Spike in Meningitis
Infection preventionists should be aware of increasing cases of invasive Neisseria meningitidis, which currently are causing an 18% mortality rate and primarily infecting three risk groups: Black people, people with human immunodeficiency virus, and those in the age range of 30 to 60 years, the Centers for Disease Control and Prevention reports in a public health alert.
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All In: If You Share Patients, Collaborate
A regional decolonization collaborative among hospitals and long-term care facilities that commonly share patients led to decreased infections, hospitalizations, costs, and deaths caused by multidrug-resistant organisms, researchers reported.
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Healthcare Diversity, Equity Efforts Under Attack After SCOTUS Ruling
Having seen the raw inequity the pandemic exposed in the healthcare system, one would think it has become harder to deny or rationalize the lack of diversity in caregivers and higher adverse outcomes in marginalized patient populations. But one would be wrong.
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Inappropriate Diagnosis of Pneumonia Is Common in Hospitalized Patients
A cohort study that included 48 hospitals in Michigan found that 12% of patients treated for community-acquired pneumonia were diagnosed inappropriately. Older age, dementia, and presenting with acute change in mental status increased the risk for misdiagnosis.
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Mosquito-Borne Diseases in the 21st Century
Hundreds of millions of people across the globe are affected by mosquito-borne diseases each year, and travelers who do not exercise caution and take preventive measures are at especially high risk. Mosquito-borne diseases are found mostly in tropical and subtropical destinations, ranging from America to Africa and Asia. Chikungunya virus, dengue, filariasis, Japanese encephalitis virus, malaria, West Nile virus, yellow fever, and Zika virus are particular sources of concern for travelers venturing into regions where these vectors abound. This article will focus on these mosquito-borne illnesses, especially the flaviviruses.